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Systemic inflammation and decline in lung function in a general population: a prospective study.

Andrew W Fogarty¹, Stuart Jones, John R Britton

¹Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK. andrew.fogarty@nottingham.ac.uk

|January 26, 2007

Summary

Systemic inflammation, indicated by C-reactive protein (CRP), is linked to lower lung function (FEV1). However, this study found no evidence that CRP levels predict the decline in lung function over time.

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Area of Science:

Pulmonary Medicine
Inflammation Research
Epidemiology

Background:

Systemic inflammation, measured by C-reactive protein (CRP), is hypothesized to contribute to chronic obstructive pulmonary disease (COPD) pathophysiology.
Previous research suggests an association between elevated CRP levels and reduced forced expiratory volume in 1 second (FEV1).
Limited large-scale prospective studies have investigated the relationship between CRP and lung function decline in the general population.

Purpose of the Study:

To prospectively assess the association between serum C-reactive protein (CRP) levels and the decline in lung function.
To investigate if systemic inflammation influences the rate of lung function deterioration over time.

Main Methods:

A community-based cohort study involving 2442 randomly selected adults in 1991, with repeated measurements in 1301 individuals in 2000.
Lung function parameters, including forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), were measured.
Serum CRP levels were analyzed from samples collected in 1991 and 2000.

Main Results:

Cross-sectional analyses in both 1991 and 2000 revealed an inverse relationship between serum CRP levels and FEV1/FVC.
Each mg/l increment in serum CRP was associated with a reduction in FEV1 by -9 ml (1991) and -7 ml (2000) after adjusting for confounders.
No significant association was found between baseline serum CRP levels and the decline in FEV1 or FVC over the 9-year follow-up period.

Conclusions:

While serum CRP levels show an inverse association with lung function cross-sectionally, they do not appear to predict the decline in lung function over a 9-year period.
The findings suggest that systemic inflammation, as measured by CRP, may not be a significant driver of lung function deterioration in the general population over this timeframe.