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Related Experiment Videos

Changes in spinal excitability after PAS.

Sabine Meunier1, Heike Russmann, Marion Simonetta-Moreau

  • 1Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. meunier.sabine@free.fr

Journal of Neurophysiology
|January 26, 2007
PubMed
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Repetitive peripheral stimulation paired with transcortical magnetic stimulation (PAS) can alter brain and spinal cord excitability. Our study shows that PAS induces parallel changes in both cortical and spinal excitability, challenging previous assumptions.

Area of Science:

  • Neuroscience
  • Motor Control
  • Neuroplasticity

Background:

  • Noninvasive brain stimulation techniques like paired associative stimulation (PAS) are used to induce neuroplasticity.
  • Previous research suggested PAS-induced plasticity is solely cortical, based on F wave data.
  • F waves are a measure of spinal reflex excitability.

Purpose of the Study:

  • To investigate the origin of PAS-induced neuroplasticity.
  • To determine if PAS affects spinal excitability in addition to cortical excitability.
  • To re-evaluate the established understanding of PAS-induced plasticity.

Main Methods:

  • Used H reflex recruitment curves to assess spinal excitability.
  • Applied repetitive peripheral stimulation paired with transcortical magnetic stimulation (PAS).

Related Experiment Videos

  • Compared changes in spinal excitability with changes in cortical excitability.

    • Main Results:

    • Demonstrated that PAS induces parallel changes in both cortical and spinal excitability.
    • Showed significant alterations in H reflex recruitment curves following PAS.
    • Contradicted the previous notion that PAS-induced plasticity is exclusively cortical.

    Conclusions:

    • PAS is capable of inducing plasticity at both cortical and spinal levels.
    • The H reflex is a more sensitive measure than F waves for detecting spinal excitability changes induced by PAS.
    • This finding necessitates a revision of the current understanding of PAS-induced neuroplasticity.