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Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
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Related Experiment Video

Updated: Jul 17, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Wnt signalling: variety at the core.

Stefan Hoppler¹, Claire Louise Kavanagh

¹Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK. s.p.hoppler@abdn.ac.uk

Journal of Cell Science

|January 26, 2007

Summary

The Wnt/beta-catenin pathway uses TCF/LEF factors to control genes. Diverse TCF/LEF forms are crucial for development, stem cell function, and diseases like cancer.

Area of Science:

Molecular Biology
Developmental Biology
Cell Signaling

Background:

The Wnt/beta-catenin pathway is a fundamental cell-cell communication system.
It controls gene expression through TCF/LEF DNA-binding proteins.
This pathway is vital for numerous cellular processes in animals.

Purpose of the Study:

To investigate the functional significance of TCF/LEF factor diversity.
To understand the role of TCF/LEF isoforms in vertebrate development and disease.

Main Methods:

Analysis of TCF/LEF gene families in vertebrates.
Examination of alternative splicing and promoter usage.
Review of experimental evidence from various model systems.

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The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Related Experiment Videos

Last Updated: Jul 17, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Main Results:

Vertebrates possess four Tcf/Lef genes.
Alternative splicing and promoter use generate diverse TCF/LEF isoforms.
Evidence suggests functional importance of these isoforms.

Conclusions:

TCF/LEF factor diversity is critical for precise Wnt regulation.
This diversity mediates tissue- and stage-specific effects.
Implications for embryonic development, stem cell differentiation, and cancer are highlighted.