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Updated: Jul 17, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Wnt signalling: variety at the core
Stefan Hoppler1, Claire Louise Kavanagh
1Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK. s.p.hoppler@abdn.ac.uk
Abstract:
The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.
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