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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Sinus pericranii associated with craniosynostosis.

Nobuyuki Mitsukawa¹, Kaneshige Satoh, Takashi Hayashi

¹Department of Plastic and Reconstructive Surgery, St. Mary's Hospital, Kurume, Japan. nmitsu@air.linkclub.or.jp

The Journal of Craniofacial Surgery

|January 26, 2007

Summary

Sinus pericranii, a rare vascular tumor, was successfully treated in seven craniosynostosis patients using minimally invasive surgery. This approach avoided craniotomy and showed no recurrence, offering a safe treatment option.

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Area of Science:

Vascular Surgery
Pediatric Neurosurgery
Craniofacial Surgery

Background:

Sinus pericranii is a rare vascular malformation connecting the scalp veins to the dural venous sinuses.
Approximately 170 cases have been reported since 1850, with few associated with craniosynostosis.
This study focuses on seven pediatric cases of sinus pericranii linked to craniosynostosis.

Observation:

Tumors presented as soft subcutaneous masses, typically in the parietal or frontal regions.
Clinical signs included enlargement with increased intracranial pressure (recumbent position, crying) and disappearance when upright.
Preoperative diagnosis was confirmed via imaging (MRI) and clinical presentation.

Findings:

Seven cases of sinus pericranii associated with craniosynostosis (Apert, Crouzon, oxycephaly, trigonocephaly) are presented.
A minimally invasive technique involving tumor excision and electrocoagulation of communication sites was employed.
No significant intraoperative hemorrhage or postoperative recurrence was observed.

Implications:

Minimally invasive surgery is a safe and effective treatment for sinus pericranii in craniosynostosis patients.
This approach avoids the need for craniotomy, reducing surgical risks.
Early diagnosis and treatment can prevent complications associated with increased intracranial pressure.