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03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Cronkhite-Canada syndrome presenting as eosinophilic gastroenteritis
Robert D Anderson1, Rikin Patel, J Kent Hamilton
1Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA.
Proceedings (Baylor University. Medical Center)
|January 26, 2007
Summary
Cronkhite-Canada syndrome (CCS) is a rare disorder with gastrointestinal polyposis and skin/nail changes. This case highlights CCS presenting with eosinophilic infiltration in gastric and duodenal biopsies.
Area of Science:
- Gastroenterology
- Rare Diseases
- Clinical Case Reports
Background:
- Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal disorder.
- Its etiology remains unknown, and diagnosis is primarily clinical.
- Key features include alopecia, hyperpigmentation, polyposis, and onychodystrophy.
Purpose of the Study:
- To report a unique case of Cronkhite-Canada syndrome.
- To describe the presence of eosinophilic infiltrate in gastric and duodenal biopsies in a CCS patient.
- To review existing literature on this rare syndrome.
Main Methods:
- Clinical diagnosis of Cronkhite-Canada syndrome.
- Review of patient's gastric and duodenal biopsies.
- Literature review of published CCS cases.
Main Results:
- The patient presented with classic symptoms of CCS.
- Gastric and duodenal biopsies revealed significant eosinophilic infiltration.
- Literature review confirmed the rarity of CCS and its varied presentations.
Conclusions:
- Cronkhite-Canada syndrome is a rare disorder with diverse clinical manifestations.
- Eosinophilic infiltrate may be a notable finding in CCS gastrointestinal biopsies.
- Further research is needed to elucidate the etiology and pathophysiology of CCS.
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