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Updated: Jul 17, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Metal-driven ligand assembly in the synthesis of cyclodextrin [2] and [3]rotaxanes
Andrew G Cheetham1, Timothy D W Claridge, Harry L Anderson
1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Rd, Oxford, UK OX1 3TA.
Abstract:
Cyclodextrin [2] and [3]rotaxanes have been synthesised by use of a metal-driven ligand formation methodology. The kinetically stable cobalt(III) complexes formed act as either linking or capping groups, the function being selected by manipulation of the reaction conditions to promote the formation of either 2:1 or 1:1 complexes, respectively. In all cases, mixtures of isomers containing different alpha-cyclodextrin orientations were observed. All three orientational isomers of the [3]rotaxane were isolated and structurally characterized by 2D NMR.
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