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6-Methoxy-N-methyl-1,2,3,4-tetrahydro-beta-carboline from Evodiae Fructus
1Department and Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan.
Planta Medica
|January 26, 2007
Summary
A novel alkaloid, 6-methoxy-N-methyl-1,2,3,4-tetrahydro-beta-carboline, was identified in Evodiae Fructus. This compound shows moderate interaction with serotonin 5-HT(1A) and 5-HT(2) receptors.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Medicinal Chemistry
Background:
- Evodiae Fructus (EF) is a traditional Chinese herbal medicine.
- The chemical constituents of EF and their pharmacological activities are of significant interest.
Purpose of the Study:
- To identify and characterize novel compounds from Evodiae Fructus.
- To investigate the receptor binding profile of the isolated compound.
Main Methods:
- Receptor binding assay-directed separation.
- Spectroscopic methods for structure elucidation (e.g., NMR, MS).
- Comparison with synthetic standards.
Main Results:
- A minor alkaloid, 6-methoxy-N-methyl-1,2,3,4-tetrahydro-beta-carboline (compound 1), was isolated from EF.
- The structure of compound 1 was confirmed through spectroscopic analysis and comparison with synthetic materials.
- Compound 1 exhibited moderate binding affinity to serotonin 5-HT(1A) and 5-HT(2) receptors (Ki values of 78 and 1.2 microM, respectively).
- This marks the first report of compound 1 in EF and the genus Evodiae.
Conclusions:
- 6-methoxy-N-methyl-1,2,3,4-tetrahydro-beta-carboline is a newly identified constituent of Evodiae Fructus.
- The compound possesses pharmacological activity, interacting with specific serotonin receptors.
- This discovery contributes to the understanding of the chemical diversity and potential therapeutic applications of Evodiae Fructus.
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