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Related Experiment Video

Updated: Jul 17, 2026

HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis

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Alkamides from Cissampelos glaberrima.

S L Rosario¹, A J da Silva, J P Parente

¹Núcleo de Pesquisas de Produtos Naturais, Centra de Ciências de Saúde, Universidade Federal do Rio de Janeiro, CEP 21941-950, Rio de Janeiro, RJ, Brazil.

|August 1, 1996

Summary

Two alkamides were isolated from Cissampelos glaberrima roots. These compounds, including deca-2E,4E-dienoic acid isobutylamide and octa-2E,4E-dienoic acid isobutylamide, were identified using spectral and mass spectrometry methods.

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Published on: June 13, 2022

Area of Science:

Phytochemistry
Natural Product Chemistry

Background:

Cissampelos glaberrima (Menispermaceae) is a plant species known for its potential medicinal properties.
Alkamides are a class of natural compounds with diverse biological activities.

Purpose of the Study:

To isolate and characterize alkamides from the roots of Cissampelos glaberrima.
To identify novel alkamide compounds within the plant extract.

Main Methods:

Isolation of compounds using chromatographic techniques.
Structure elucidation through comprehensive spectral analysis (NMR, MS).
Identification of trace compounds using mass spectrometry.

Main Results:

Two known alkamides, deca-2E,4E-dienoic acid isobutylamide (1) and octa-2E,4E-dienoic acid isobutylamide (2), were successfully isolated.
The structures of compounds 1 and 2 were confirmed via spectral and physical data.
Traces of two new alkamides, decen-2-oic acid isobutylamide (3) and decanoic acid isobutylamide (4), were identified.

Conclusions:

The roots of Cissampelos glaberrima contain significant alkamide constituents.
The study expands the knowledge of alkamide diversity in the Menispermaceae family.
Further investigation into the biological activities of these identified alkamides is warranted.