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Alpha-fetoprotein in tumours derived from cystic and simple embryoid bodies
M Monzó1, J M de Anta, B Peris
1Department of Morphological Sciences, Faculty of Medicine, University of Barcelona, Spain.
Abstract:
Cellular aggregates called embryoid bodies (EB) have been obtained from the experimental teratocarcinoma (TC) 0TT6050. Two morphological types of EB can be differentiated, which are injected subcutaneously into isogenic 129/Sv mice. The tumors are collected 20 and 30 days after EB injection and processed histologically, and immunohistochemically with anti-alpha-fetoprotein (alpha-FP) antibodies. Our results indicate that the histological pattern of the tumors is related to the degree of morphological organization of the EB used.