Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic polymorphisms and disease prevention.

Martin C Mahoney1

  • 1Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. Martin.Mahoney@RoswellPark.org

Pediatric Blood & Cancer
|January 26, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do lab-based assessments of pretreatment smoking reinforcement and cue-specific craving predict smoking cessation with varenicline?

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors·2025
Same author

Cigarette smoking and chronic disease in the United States, 2021-2023.

Preventive medicine·2025
Same author

Sex-Specific Mediation of Pre-Quit Smoking Reduction: Secondary Analysis of a Randomized Controlled Trial Extending Varenicline Preloading.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2025
Same author

Daily Cigarette Abstinence and Smoking Rate With Varenicline: Relationships With Treatment, Craving, and Affect During the First Week of the Quit Attempt.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2025
Same author

Correction to: Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in waves 1 through 5 (2013-2019) of the population assessment of tobacco and health (PATH) study.

Respiratory research·2025
Same author

Evaluating mediators of the effect of varenicline preloading on smoking abstinence in a randomized controlled trial.

Addiction (Abingdon, England)·2025
Same journal

Comment on: "The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience"-The Evolving Role of the BIT Regimen.

Pediatric blood & cancer·2026
Same journal

Extramedullary Intradural Spinal Tumor in an Infant With Neurocutaneous Melanosis.

Pediatric blood & cancer·2026
Same journal

The Role of Hematopoietic Cell Transplantation in Ataxia-Telangiectasia.

Pediatric blood & cancer·2026
Same journal

Pediatric T-Lymphoblastic Lymphoma With T(9;17) and MIR142HG::NOTCH1 Fusion Successfully Treated by Allogeneic Hematopoietic Stem Cell Transplantation in First Complete Remission.

Pediatric blood & cancer·2026
Same journal

Reply to: Comment on: Investigating Biomarkers for Inborn Errors of Immunity in a Prospective Study of Patients With Autoimmune Cytopenia.

Pediatric blood & cancer·2026
Same journal

Comment on: Investigating Biomarkers for Inborn Errors of Immunity in a Prospective Study of Patients With Autoimmune Cytopenia.

Pediatric blood & cancer·2026
See all related articles

Molecular epidemiology reveals how inherited genetic variations influence cancer risk, particularly concerning smoking and nutrition. This knowledge aids in targeted prevention and personalized health strategies.

Area of Science:

  • Epidemiology
  • Genetics
  • Public Health

Background:

  • Traditional epidemiology traditionally focused on acquired factors influencing disease risk.
  • Molecular epidemiology integrates genetic factors, such as genetic polymorphisms, to provide a more comprehensive understanding of disease susceptibility.
  • Individual susceptibility to cancer is influenced by genetic variations in enzyme activity, DNA repair mechanisms, and other cancer-related genes.

Purpose of the Study:

  • To illustrate the interplay between genetic polymorphisms and disease prevention using tobacco use and nutrition as examples.
  • To highlight how molecular epidemiology can inform targeted prevention strategies and personalized medicine.
  • To demonstrate the application of genetic insights in reinforcing healthy lifestyles and improving medical surveillance.

Related Experiment Videos

Main Methods:

  • Utilizes principles of traditional epidemiology.
  • Incorporates the study of genetic polymorphisms (e.g., in phase I and phase II enzymes, DNA repair genes).
  • Examines gene-environment interactions, specifically focusing on tobacco use and nutrient metabolism.

Main Results:

  • Genetic factors influence individual susceptibility to the health risks associated with smoking, affecting initiation, dependence, and nicotine metabolism.
  • Gene-nutrient interactions and polymorphic enzyme pathways in nutrient metabolism can modify cancer risk.
  • Knowledge of genetic polymorphisms can guide the development of targeted clinical prevention studies for high-risk individuals.

Conclusions:

  • Molecular epidemiology offers valuable insights into disease risk beyond traditional factors.
  • Understanding genetic polymorphisms can enhance disease prevention efforts by identifying at-risk populations.
  • This knowledge supports personalized medicine, behavior modification, and improved health surveillance strategies.