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Updated: Jul 17, 2026
Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
In vitro evaluation of a double-membrane-based voice-producing element for laryngectomized patients
Johannes W Tack1, Gerhard Rakhorst, Eduard B van der Houwen
1Department of BioMedical Engineering, University Medical Center Groningen, University of Groningen, Groningen, 9713 AV Groningen, the Netherlands.
Background:
A sound generator based on a double-membrane design that fits into a regular tracheoesophageal shunt valve may improve voice quality after total laryngectomy in patients rehabilitated with surgical voice prostheses.
Methods:
Voice-producing element (VPE) prototypes were manufactured using medical grade biocompatible materials and tested in vitro under physiological conditions.
Results:
Basic sound, containing multiple harmonics, was successfully produced under physiologic air pressure and airflow conditions. The fundamental frequency and sound pressure level (SPL) is controlled by changing the driving pressure, thus enabling sufficient intonation for day-to-day speech. The obtained frequency range (190-350 Hz) is appropriate for producing a female voice. The low noise-to-harmonics ratio (mean 0.15) and also the efficiency of sound production (5.5 x 10(-5) at 80 dB(A) and 0.15 m microphone distance) is comparable to that of normal vocal folds.
Conclusions:
Functional restoration of the voice after laryngectomy with a double-membrane VPE appears to be a feasible concept for female laryngectomized patients with a hypotonic, or atonic pharyngoesophageal segment.
