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Updated: Jul 17, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
[Hepatology: yesterday, today and (maybe) tomorrow]
Luigi Pagliaro1, Bruno Gridelli, Antonio Craxì
1Università, Palermo.
Insights
Hepatology has positively impacted liver disease care over 50 years through improved prevention, diagnosis, and treatment, enhancing patient survival and quality of life. This review examines key advancements and past medical errors in the field.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Context:
- Hepatology emerged as a distinct medical specialty in the mid-20th century.
- Liver diseases represent a significant global health burden due to their severity and prevalence.
- The field has evolved substantially over the past five decades.
Purpose:
- To review the major advancements in hepatology over the last 50 years.
- To identify and analyze past errors and obsolete treatments in liver disease management.
- To speculate on the reasons behind these historical deviations in medical practice.
Summary:
- The past 50 years of hepatology have yielded significant positive outcomes, including reduced viral hepatitis transmission and improved patient survival and quality of life.
- Despite progress, the field has encountered instances of misguided or ineffective treatments and diagnostic approaches.
- This review critically examines both the successes and failures in hepatology, offering insights into the evolution of liver disease management.
Impact:
- Highlights the substantial benefits of specialized hepatology care in improving outcomes for patients with liver conditions.
- Provides a historical perspective on the development of liver disease treatments and diagnostics.
- Offers valuable lessons from past medical errors to inform current and future clinical practice in hepatology.
Abstract:
Hepatology was born as a separate medical specialty around the fifties of the last century, its importance progressively grows because of the severity and high prevalence of the liver diseases. The net balance of 50 years of hepatology is definitely positive: prevention (e.g. the fall of post-transfusion HB and HC virus infections), diagnosis and better treatments have achieved better survival and quality of life in liver disease. However, deviations, errors and obsolescence of once highly credited judgements and treatments have occurred, as in any other area of medicine. This review looks back at the main pieces of the progress, and reports some previous errors and inappropriate treatments, speculating on their possible reasons.
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