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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

[HIV infection: emerging issues and new challenges].

Leonardo Calza1, Roberto Manfredi, Francesco Chiodo

  • 1Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Policlinico S.Orsola, Alma Mater Studiorum Università, Bologna. leonardo.calza@unibo.it

Recenti Progressi in Medicina
|January 27, 2007
PubMed
Summary

Highly active antiretroviral therapy (HAART) significantly reduces HIV morbidity and mortality but causes metabolic complications like lipodystrophy and hyperlipidemia. The long-term effects and the need for an HIV vaccine remain critical challenges.

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Comprehensive &amp; Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
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Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

Comprehensive &amp; Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Area of Science:

  • Infectious Diseases
  • Virology
  • Metabolic Medicine

Context:

  • Highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV) management.
  • Significant reductions in HIV-related morbidity and mortality have been observed.
  • However, HAART is linked to serious clinical and metabolic complications.

Purpose:

  • To review the impact of HAART on HIV natural history.
  • To highlight the metabolic complications associated with HAART.
  • To discuss the challenges in HIV treatment and vaccine development.

Summary:

  • HAART has drastically improved outcomes for HIV-infected individuals.
  • Common HAART-associated metabolic issues include lipodystrophy, hyperlipidemia, insulin resistance, and diabetes.
  • Long-term consequences, such as premature coronary artery disease, are a concern.
  • Limited access to HAART in developing nations hinders AIDS pandemic control.
  • Despite decades of research, an effective HIV vaccine remains elusive.

Impact:

  • HAART has shifted HIV from a fatal disease to a manageable chronic condition.
  • Understanding and managing HAART-associated metabolic complications is crucial for patient health.
  • The ongoing need for an accessible HIV vaccine underscores the persistent global health challenge posed by HIV/AIDS.