Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non inherited hemoglobin anomalies.

S P Dibenedetto1, G Russo Mancuso, A Di Cataldo

  • 1Cattedra di Ematologia Pediatrica, Università di Catania, Italy.

Haematologica
|September 1, 1991
PubMed
Summary

This review covers hemoglobin anomalies without globin gene changes, including increased fetal hemoglobin and variations like Hb H and Bart's Hb. These conditions highlight diverse hemoglobinopathies beyond direct genetic mutations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-invasive brain stimulation of cerebellar and cortical targets: A systematic review and ALE meta-analysis of cognitive and connectivity outcomes in adults.

Neuroscience and biobehavioral reviews·2026
Same author

Mid-transverse colon cancer and extended versus transverse colectomy: Results of the Italian society of surgical oncology colorectal cancer network (SICO CCN) multicenter collaborative study.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2020
Same author

Importance of a careful clinical evaluation in the diagnosis of cystic pancreatic tumors.

Il Giornale di chirurgia·2020
Same author

Laparoscopic nephrectomy in children with Wilms tumor. Considerations after 10 years of experience.

Journal of biological regulators and homeostatic agents·2019
Same author

Thyroid hemiagenesis associated with multinodular goiter and Hashimoto's thyroiditis.

Il Giornale di chirurgia·2018
Same author

Unusual presentation of retroperitoneal Schwannoma: case report.

Il Giornale di chirurgia·2018

Area of Science:

  • Hematology
  • Molecular Biology
  • Genetics

Background:

  • Hemoglobinopathies encompass a range of blood disorders.
  • Some hemoglobin anomalies occur without identifiable alterations in globin genes.
  • Understanding these conditions is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To review genetic and acquired conditions featuring hemoglobin anomalies.
  • To highlight cases where globin gene modifications are not detectable.
  • To provide an overview of various non-mutational hemoglobin variations.

Main Methods:

  • Literature review of documented hemoglobinopathies.
  • Analysis of cases with abnormal hemoglobin presence.
  • Categorization of conditions based on hemoglobin type and origin.

Main Results:

  • Identified conditions include increased fetal hemoglobin (alpha 2 gamma 2).
  • Variations in hemoglobin A2 concentration were noted.
  • Presence of Hemoglobin H (beta 4), Bart's Hemoglobin (gamma 4), Hb Köelliker, and modified hemoglobins (glycosylated, carbamylated, acetylated) were reviewed.

Conclusions:

  • Hemoglobin anomalies can manifest without detectable globin gene modifications.
  • Diverse hemoglobin variants, including fetal and abnormal forms, exist.
  • Further research into the mechanisms of these hemoglobinopathies is warranted.

Related Experiment Videos