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Related Experiment Videos

Amphetamines for improving recovery after stroke.

L Martinsson1, H Hårdemark, S Eksborg

  • 1AstraZeneca, R&D Södertälje, Study Delivery II, Södertälje, Sweden, SE-151 85. louise.martinsson@astrazeneca.com

The Cochrane Database of Systematic Reviews
|January 27, 2007
PubMed
Summary
This summary is machine-generated.

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Amphetamine treatment in stroke patients showed potential benefits in motor function but did not significantly reduce death or dependence. More research is needed to confirm these findings and assess safety in stroke recovery.

Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Trials

Background:

  • Animal studies suggest amphetamines aid recovery from focal cerebral ischemia.
  • Amphetamine treatment could significantly impact human stroke recovery if effects are similar.

Purpose of the Study:

  • To evaluate the efficacy and safety of amphetamine treatment in patients following a stroke.

Main Methods:

  • Systematic review of randomized controlled trials comparing amphetamine with placebo.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, and CINAHL up to January 2006.
  • Data extraction and quality assessment performed independently by two reviewers.

Main Results:

  • Ten trials with 287 patients were included; trial quality varied but was generally high.

Related Experiment Videos

  • No significant reduction in death or dependence was observed (Peto OR 1.5, 95% CI 0.6 to 3.3).
  • Amphetamine use was associated with increased systolic and diastolic blood pressure and heart rate.
  • Evidence suggested improved motor function recovery from baseline (WMD -6.1 points; 95% CI -10.4 to -1.9).

    • Conclusions:

    • Current evidence is insufficient to draw definitive conclusions on amphetamine's effects in stroke recovery due to limited patient numbers.
    • Observed benefits in motor function and trends in mortality may be influenced by baseline imbalances or study bias.
    • Further research is warranted to clarify the role of amphetamines in stroke rehabilitation.