Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diuretics for preventing pre-eclampsia.

D Churchill1, G D G Beevers, S Meher

  • 1Royal Wolverhampton Hospitals NHS Trust, Department of Obstetrics and Gynaecology, New Cross Hospital, Wednesfield, Wolverhampton, West Midlands, UK, WV10 0QP. david.churchill@rwh-tr.nhs.uk

The Cochrane Database of Systematic Reviews
|January 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical algorithms for the management of intrapartum maternal urine abnormalities.

BJOG : an international journal of obstetrics and gynaecology·2022
Same author

Intrapartum care algorithms for liquor abnormalities: oligohydramnios, meconium, blood and purulent discharge.

BJOG : an international journal of obstetrics and gynaecology·2022
Same author

Constructing evidence-based clinical intrapartum care algorithms for decision-support tools.

BJOG : an international journal of obstetrics and gynaecology·2022
Same author

The origin and stability of nanostructural hierarchy in crystalline solids.

Science advances·2018
Same author

Identification of the Novel Tooth-Specific Transcription Factor AmeloD.

Journal of dental research·2018
Same author

Core outcome sets for prevention and treatment of postpartum haemorrhage: an international Delphi consensus study.

BJOG : an international journal of obstetrics and gynaecology·2018
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Diuretics do not prevent pre-eclampsia or its complications. Studies found no clear benefits but noted increased risks of nausea and vomiting, leading to treatment discontinuation. Therefore, diuretics are not recommended for preventing pre-eclampsia.

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology

Background:

  • Diuretics are used for blood pressure and edema in non-pregnant individuals.
  • Historically, diuretics were used in pregnancy to prevent pre-eclampsia, but this practice became controversial due to potential risks to mother and fetus, including impaired fetal growth.

Purpose of the Study:

  • To evaluate the efficacy of diuretics in preventing pre-eclampsia and its associated complications.

Main Methods:

  • Systematic review of randomized controlled trials.
  • Searched Cochrane Pregnancy and Childbirth Group's Trials Register, Cochrane Central Register of Controlled Trials, and EMBASE.
  • Independent selection and data extraction by three reviewers.

Main Results:

  • Five trials involving 1836 women were included; all were of uncertain quality.

Related Experiment Videos

  • Thiazide diuretics showed no significant differences compared to placebo for pre-eclampsia, perinatal death, or preterm birth.
  • Increased risks of nausea and vomiting were observed with diuretics, leading to higher rates of treatment discontinuation.

    • Conclusions:

    • Insufficient evidence exists to reliably conclude on the effects of diuretics for pre-eclampsia prevention.
    • No clear benefits were identified for using diuretics to prevent pre-eclampsia.
    • Given the adverse effects, the use of diuretics for pre-eclampsia prevention is not recommended.