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Passiflora for anxiety disorder.

L S Miyasaka1, A N Atallah, B G O Soares

  • 1Universidade Federal de São Paulo, Brazilian Cochrane Centre, Rua de Pedro Toledo 598, Vila Clementino, Sao Paulo, SP, Brazil, 04039-001. lincoln.miyasaka@terra.com.br

The Cochrane Database of Systematic Reviews
|January 27, 2007
PubMed
Summary
This summary is machine-generated.

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Limited research suggests passionflower extract (Passiflora) may be comparable to benzodiazepines for anxiety, but more high-quality studies are needed to confirm its effectiveness and safety.

Area of Science:

  • Herbal Medicine Research
  • Psychiatry and Mental Health
  • Evidence-Based Practice

Background:

  • Anxiety disorders are highly prevalent in primary care.
  • Herbal remedies are widely used globally for various conditions.
  • Passiflora (passionflower extract) is a popular herbal anxiolytic candidate.

Purpose of the Study:

  • To systematically evaluate the efficacy and safety of Passiflora for treating anxiety disorders.
  • To synthesize findings from randomized controlled trials (RCTs) on Passiflora's anxiolytic effects.

Main Methods:

  • Comprehensive search of electronic databases (Cochrane, Medline, Lilacs) and reference lists.
  • Inclusion of randomized and quasi-randomized controlled trials assessing Passiflora for various anxiety conditions.

Related Experiment Videos

  • Data extraction and quality assessment by independent reviewers, with statistical analysis using relative risk and weighted mean difference.

    • Main Results:

    • Only two studies with 198 participants met the inclusion criteria.
    • One study indicated no significant difference in efficacy between Passiflora and benzodiazepines.
    • Similar dropout rates were observed; minor benefits of Passiflora (job performance, reduced drowsiness) were not statistically significant.

    Conclusions:

    • Current evidence from RCTs is insufficient to draw definitive conclusions on Passiflora's effectiveness for anxiety.
    • There is a need for larger, high-quality RCTs comparing Passiflora to placebo and other anxiety medications, including antidepressants.