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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

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Related Experiment Video

Updated: Jul 17, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Risperidone for autism spectrum disorder.

O S Jesner1, M Aref-Adib, E Coren

  • 1School for Policy Studies, University of Bristol, No 8 Priory Road, Bristol, UK, BS8 1TZ. orajesner@yahoo.co.uk

The Cochrane Database of Systematic Reviews
|January 27, 2007
PubMed
Summary

Risperidone shows some benefits for autism symptoms like irritability and social withdrawal, but weight gain is a significant side effect. More research is needed due to limited data and small study sizes.

Related Experiment Videos

Last Updated: Jul 17, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Pharmacology

Background:

  • Autism spectrum disorder (ASD) presents with diverse behavioral and communicative challenges.
  • Therapies for ASD target core and non-core features, including atypical antipsychotics.
  • Risperidone, an atypical antipsychotic, has demonstrated potential benefits for specific ASD symptoms.

Purpose of the Study:

  • To evaluate the efficacy and safety of risperidone in individuals diagnosed with autism spectrum disorder.

Main Methods:

  • A systematic search of multiple electronic databases (CENTRAL, MEDLINE, EMBASE, PsycINFO, CINAHL, LILACS, Clinicaltrials.gov, ZETOC, NRR) was conducted up to April 2006.
  • Inclusion criteria focused on randomized controlled trials comparing risperidone to placebo in ASD patients, requiring standardized outcome measures.
  • Data from three identified randomized controlled trials were independently evaluated and analyzed, including unpublished data.

Main Results:

  • Limited evidence suggests risperidone may benefit irritability, repetitive behaviors, and social withdrawal in ASD.
  • The most prominent adverse effect observed was significant weight gain.
  • The findings are based on a small number of trials with limited sample sizes.

Conclusions:

  • Risperidone may offer benefits for certain features of autism spectrum disorder.
  • However, the available data are limited, with small sample sizes and a lack of standardized outcome measures and long-term follow-up.
  • Further research is essential to establish the clinical efficacy and safety of risperidone for ASD.