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Updated: Jul 17, 2026

Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy

Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy

Published on: March 10, 2023

Elective surgery for benign liver tumours.

A Colli¹, M Fraquelli, S Massironi

¹Ospedale "A Manzoni" Lecco, Department of Internal Medicine, Via dell'Eremo, 9/11, Lecco, Italy, 23900. a.colli@ospedale.lecco.it

The Cochrane Database of Systematic Reviews

|January 27, 2007

Summary

No randomized trials exist for elective surgery in benign liver tumors. Further research is needed to determine the benefits and harms of surgical intervention for these conditions.

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Area of Science:

Hepatology
Surgical Oncology
Gastroenterology

Background:

Benign liver tumors, including hemangioma, focal nodular hyperplasia, and hepatic adenoma, vary in prevalence and prognosis.
Hepatic adenoma can lead to complications like spontaneous rupture and malignant transformation.
Elective surgery for benign liver tumors is debated, with indications including diagnostic uncertainty, symptoms, and complication prevention.

Purpose of the Study:

To evaluate the efficacy and safety of elective surgical resection for benign liver tumors.
To identify and synthesize evidence from randomized clinical trials comparing elective surgery with non-surgical management.

Main Methods:

Comprehensive literature search of multiple databases (Cochrane Hepato-Biliary Group, CENTRAL, MEDLINE, EMBASE, CancerLit, SCI-EXPANDED) up to December 2005.

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Last Updated: Jul 17, 2026

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Inclusion of major hepatological and surgical congress proceedings and reference list reviews.

Focus on randomized clinical trials in adult patients with benign liver tumors without emergency indications, comparing elective resection to no intervention or sham surgery.

Main Results:

No randomized clinical trials were identified that met the inclusion criteria.
Existing case series were small and heterogeneous, with reported mortality rates ranging from 1% to 17% in studies that reported mortality.

Conclusions:

There is insufficient evidence to support or refute the use of elective surgery for benign liver tumors.
High-quality, large-scale, long-term randomized clinical trials are required to establish the benefits and risks of elective surgery.