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Interventions for treating lymphocytic colitis.

N Chande1, J W D McDonald, J K Macdonald

  • 1LHSC - South Street Hospital, Mailbox 55, 375 South Street, London, Ontario, Canada, N6A 4G5. nchande2@uwo.ca

The Cochrane Database of Systematic Reviews
|January 27, 2007
PubMed
Summary
This summary is machine-generated.

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Bismuth subsalicylate may help lymphocytic colitis, but a small trial showed no significant improvement. More research is needed to confirm effective treatments for this chronic diarrhea condition.

Area of Science:

  • Gastroenterology
  • Internal Medicine

Background:

  • Lymphocytic colitis is a significant cause of chronic diarrhea.
  • Current treatment strategies rely on limited evidence from case series or extrapolation from collagenous colitis data.
  • This review aimed to identify therapies supported by randomized controlled trials (RCTs).

Purpose of the Study:

  • To identify effective treatments for patients experiencing active lymphocytic colitis.
  • To evaluate therapies for lymphocytic colitis based on evidence from RCTs.

Main Methods:

  • Comprehensive literature search of MEDLINE, PUBMED, EMBASE, and Cochrane registers (1970-2006).
  • Inclusion of a single abstract-only RCT on bismuth subsalicylate involving 5 patients with lymphocytic colitis.
  • Data extraction using 2x2 tables and chi-square tests for statistical analysis.

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Main Results:

  • A trial of bismuth subsalicylate (262 mg nine tablets daily for 8 weeks) included 5 patients with lymphocytic colitis.
  • All 3 patients receiving active treatment showed clinical improvement, compared to none in the placebo group.
  • No statistically significant differences were observed in clinical (P=0.10) or histological (P=0.71) improvement.

Conclusions:

  • A single small trial suggests potential benefit of bismuth subsalicylate for lymphocytic colitis.
  • The trial's small sample size (5 patients) precludes definitive conclusions.
  • Larger, well-designed RCTs are essential to establish effective treatments for lymphocytic colitis.