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Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives
Franco Chimenti1, Elias Maccioni, Daniela Secci
1Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" and Centro di Biologia Molecolare del CNR, Università degli Studi di Roma "La Sapienza", Rome, Italy.
Abstract:
A series of 2-thiazolylhydrazone derivatives have been investigated for the ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO) selectively. All of the compounds showed high activity against both the MAO-A and the MAO-B isoforms with pKi values ranging between 5.92 and 8.14 for the MAO-A and between 4.69 and 9.09 for the MAO-B isoforms. Both the MAO-A and the MAO-B isoforms, deposited in the Protein Data Bank as model 2BXR and 1GOS, respectively, were considered in a computational study performed with docking techniques on the most active and MAO-B-selective inhibitor, 18.
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