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Supramolecular analytical chemistry.

Eric V Anslyn1

  • 1Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA.

The Journal of Organic Chemistry
|January 27, 2007
PubMed
Summary
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Synthetic receptors, mimicking natural ones, are increasingly vital in analytical sciences for applications like cellular imaging and fluid assays. Their cross-reactivities, once a challenge, are now crucial for emerging differential sensing techniques.

Area of Science:

  • Supramolecular Chemistry
  • Analytical Chemistry

Background:

  • Supramolecular chemistry has historically focused on synthetic receptors mimicking natural ones.
  • The demand for synthetic receptors is rapidly growing in analytical sciences.

Purpose of the Study:

  • To highlight the expanding role of synthetic receptors in various analytical applications.
  • To introduce the emerging field of Supramolecular Analytical Chemistry.

Main Methods:

  • Review of current applications of synthetic receptors.
  • Analysis of receptor selectivity and cross-reactivity.

Main Results:

  • Synthetic receptors are used in indicator chemistry, cellular imaging, and bodily fluid assays.
  • Cross-reactivity, often seen as a limitation, is essential for differential sensing.

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  • Both selective and nonselective synthetic receptors have analytical applications.

    • Conclusions:

    • Supramolecular Analytical Chemistry is an emerging field with significant future growth potential.
    • Synthetic receptors are versatile tools driving innovation in chemical analysis.