Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis C virus replication in 'autoimmune' chronic hepatitis.

S Magrin1, A Craxi, C Fabiano

  • 1Clinica Medica R, University of Palermo, Italy.

Journal of Hepatology
|November 1, 1991
PubMed
Summary

Hepatitis C virus (HCV) can cause chronic active hepatitis in patients with autoantibodies. Early diagnosis and alpha-interferon treatment are crucial for managing this specific subgroup of autoimmune hepatitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary ossification: a case report.

Frontiers in medicine·2025
Same author

Impact of organ sampling for forensic pathology: should heart and brain be retained whole?

Forensic science, medicine, and pathology·2025
Same author

Illness representation in patients with multiple sclerosis: A preliminary narrative medicine study.

Multiple sclerosis journal - experimental, translational and clinical·2024
Same author

Regional long-term analysis of dietary isotopes in Neolithic southeastern Italy: new patterns and research directions.

Scientific reports·2023
Same author

Unexpected silicon localization in calcium carbonate exoskeleton of cultured and fossil coccolithophores.

Scientific reports·2023
Same author

Correction: Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes.

Molecular psychiatry·2022

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Autoimmune chronic active hepatitis (ACAH) diagnosis can be complicated by varying anti-hepatitis C virus antibody (anti-HCV) prevalence.
  • Distinguishing HCV-related liver disease from primary autoimmune hepatitis is critical for appropriate treatment.

Purpose of the Study:

  • To confirm ELISA specificity for anti-HCV in autoantibody-positive chronic active hepatitis patients.
  • To evaluate hepatitis C virus replication using serum HCV-RNA.
  • To assess treatment response to prednisone and alpha-interferon.

Main Methods:

  • Study included 15 HBsAg-negative, ELISA anti-HCV-positive, autoantibody-positive patients with biopsy-proven chronic active hepatitis.
  • ELISA results were confirmed by immunoblot test (RIBA-HCV).

Related Experiment Videos

  • Serum HCV-RNA was quantified to assess viral replication.

    • Main Results:

    • RIBA-HCV confirmed ELISA anti-HCV positivity in all patients.
    • HCV-RNA was detected in 10 out of 15 patients.
    • Prednisone treatment showed poor response, while alpha-interferon led to prompt normalization of transaminases in non-responsive patients.

    Conclusions:

    • A distinct subgroup of autoantibody-positive chronic active hepatitis is associated with HCV infection.
    • This HCV-related subgroup requires differentiation from primary autoimmune chronic active hepatitis.
    • Alpha-interferon therapy is a promising treatment option for steroid non-responsive cases.