Related Experiment Video
Updated: Jul 17, 2026
07:07
A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Can single-kidney glomerular filtration rate be determined with contrast-enhanced CT?
1Department of Radiology, Stanford University Medical Center, 300 Pasteur Dr, H-1307, Stanford, CA 94305-5105, USA. gsommer@stanford.edu
Radiology
|January 27, 2007
Summary
Researchers explored dynamic contrast-enhanced CT scans to estimate single-kidney glomerular filtration rate (GFR) in pigs. Two methods showed significant correlation with inulin clearance, suggesting potential for noninvasive GFR assessment in patients.
Area of Science:
- Nephrology
- Radiology
- Medical Imaging
Background:
- Assessing single-kidney glomerular filtration rate (GFR) is crucial for diagnosing and managing renal diseases.
- Current methods for GFR estimation can be invasive or lack precision for individual kidneys.
Purpose of the Study:
- To evaluate the efficacy of dynamic contrast-enhanced CT (DCE-CT) scanning for estimating single-kidney GFR in a preclinical model.
- To compare the performance of different kinetic modeling techniques for DCE-CT based GFR estimation.
Main Methods:
- A pig model was utilized to simulate human renal physiology.
- Dynamic contrast-enhanced CT scans were acquired and analyzed using three distinct kinetic modeling techniques.
- GFR estimates were validated against standard inulin clearance measurements.
Main Results:
- Two of the evaluated techniques, the modified Patlak method and the gamma variate model, demonstrated significant correlation with inulin clearance-based GFR.
- These methods provided reliable estimates of single-kidney GFR in the experimental setting.
Conclusions:
- Dynamic contrast-enhanced CT scanning, particularly with the modified Patlak and gamma variate models, shows promise for noninvasive in vivo assessment of single-kidney GFR.
- This approach could potentially be translated to clinical practice for improved renal function evaluation in patients.
Related Concept Videos
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
01:25Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
01:27Imaging Studies III: Computed Tomography
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
01:02Renal Drug Excretion: Glomerular Filtration
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
01:23Renal Clearance
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...