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Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

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Kinetics of morphogen gradient formation.

Anna Kicheva¹, Periklis Pantazis, Tobias Bollenbach

¹Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, 01307 Dresden, Germany.

Science (New York, N.Y.)

|January 27, 2007

Summary

This summary is machine-generated.

Decapentaplegic (Dpp) and Wingless (Wg) morphogen spreading differs between fly wings. Dpp spreading requires endocytosis and intracellular trafficking, unlike Wg, revealing distinct cellular mechanisms for positional information.

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Area of Science:

Developmental Biology
Cell Biology
Genetics

Background:

Secreted morphogens like Decapentaplegic (Dpp) and Wingless (Wg) establish concentration gradients in developing fly wings, crucial for positional information.
Dpp exhibits a longer-range gradient compared to Wg, suggesting differences in their spreading mechanisms.

Purpose of the Study:

To investigate the kinetic parameters controlling morphogen spreading and understand the distinct mechanisms governing Dpp and Wg gradient formation.
To elucidate the cellular processes underlying the differential spreading ranges of Dpp and Wg.

Main Methods:

Quantification of four key kinetic parameters: production rate, effective diffusion coefficient, degradation rate, and immobile fraction for both Dpp and Wg.
Assessment of the role of Dynamin-dependent endocytosis in the spreading of Dpp and Wg.

Main Results:

The four kinetic parameters governing morphogen spreading showed distinct values for Dpp compared to Wg.
Dynamin-dependent endocytosis was identified as essential for Dpp spreading but not for Wg spreading.

Conclusions:

The cellular mechanisms responsible for the spreading of Dpp and Wg are fundamentally different.
Dpp spreading relies on endocytic and intracellular trafficking pathways, highlighting a unique mechanism for its long-range signaling.