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A pilot study in sub-SMAS face transplantation: defining donor compatibility and assessing outcomes in a cadaver
Alessio Baccarani1, Keith E Follmar, Rajesh R Das
1Durham, N.C. From the Divisions of Plastic, Reconstructive, Maxillofacial, and Oral Surgery, and Neuroradiology, Duke University Medical Center.
Background:
Face transplantation may become a viable alternative in the treatment of patients with severe acquired facial deformity. In this study, the authors investigate morphological compatibility between donor and recipient by assessing chimeric outcomes in a human cadaver model.
Methods:
Four faces were harvested from fresh human cadaver specimens in a surgical plane deep to the galea, to the superficial musculoaponeurotic system, and to the platysma. The faces were subsequently exchanged among the four donor crania, simulating full-face transplantations. Eight cranium-face chimera complexes were created and analyzed with standardized photography and with volumetric computed tomographic radiography.
Results:
Four morphological parameters to consider in determining donor/recipient compatibility were defined: (1) skin color and texture, (2) head size, (3) soft-tissue features, and (4) gender.
Conclusion:
Careful selection of face donors based on compatibility criteria will aid in ensuring that the posttransplant outcome is morphologically similar to the recipient's native face.
