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Updated: Jul 17, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

[Breast cytopathology bestiary].

Marie-Françoise Bretz-Grenier1

  • 1Cabinet de Pathologie, 68 rue du Faubourg National, 67000 Strasbourg. Bretz-grenier@wanadoo.fr

Annales De Pathologie
|January 27, 2007
PubMed
Summary

Diagnosing breast tubular and lobular carcinomas via cytology can be challenging. Recognizing unique cell cluster patterns, resembling animals, aids in accurate diagnosis when classical signs are absent.

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Area of Science:

  • Cytopathology
  • Oncology
  • Histopathology

Context:

  • Tubular and lobular carcinomas of the breast present diagnostic challenges in cytopathology.
  • Classical morphological signs of malignancy are frequently scarce or absent in these breast cancer subtypes.
  • Accurate cytological diagnosis is crucial for timely and effective patient treatment.

Purpose:

  • To identify and report peculiar cytological patterns in breast carcinomas.
  • To highlight the diagnostic utility of recognizing specific cell cluster morphologies.
  • To provide a reference for cytopathologists facing difficult breast cancer cases.

Summary:

  • This study reviewed cytological smears of breast carcinomas with histological confirmation.
  • Peculiar cytological aspects, often mimicking animal shapes (e.g., butterfly, eagle, dog), were identified.
  • These unique patterns were found to be helpful diagnostic indicators, especially when conventional signs are lacking.

Impact:

  • Enhances diagnostic accuracy in challenging breast cytopathology cases.
  • Offers novel morphological clues for identifying tubular and lobular carcinomas.
  • Aids pathologists in differentiating benign from malignant breast lesions based on subtle cytological features.

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Last Updated: Jul 17, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
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Published on: April 23, 2021

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Published on: October 16, 2010

Using Computer-based Image Analysis to Improve Quantification of Lung Metastasis in the 4T1 Breast Cancer Model
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Published on: October 2, 2020