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Published on: January 2, 2013
[Immunologic aspects of thrombocyte transfusion]
1Institut für klinische Immunologie und Transfusionsmedizin, Universität Giessen.
This review surveys immunological aspects of platelet transfusions with regard to definition of refractoriness, clinical factors influencing platelet increments, possibilities to delay or prevent immunization, antibody specificities involved in refractory states, immunological complications of platelet transfusions and associations between production of platelet-specific antibodies (i.e. anti-Zwa and anti-Bra) and HLA class II antigens.
This review surveys immunological aspects of platelet transfusions with regard to definition of refractoriness, clinical factors influencing platelet increments, possibilities to delay or prevent immunization, antibody specificities involved in refractory states, immunological complications of platelet transfusions and associations between production of platelet-specific antibodies (i.e. anti-Zwa and anti-Bra) and HLA class II antigens.
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