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[Immunologic aspects of thrombocyte transfusion].

C Mueller-Eckhardt1

  • 1Institut für klinische Immunologie und Transfusionsmedizin, Universität Giessen.

Beitrage Zur Infusionstherapie = Contributions to Infusion Therapy
|January 1, 1991
PubMed
Summary

This review explores immune responses to platelet transfusions, defining refractoriness and factors affecting platelet counts. It discusses preventing immunization and associated antibody specificities, crucial for transfusion success.

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Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine·1997
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Diclofenac-induced immune haemolytic anaemia: simultaneous occurrence of red blood cell autoantibodies and drug-dependent antibodies.

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Therapy with intravenous immunoglobulin G (ivIgG) during pregnancy for fetal alloimmune (HPA-1a(Zwa)) thrombocytopenic purpura.

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Platelet autoantibodies (IgG, IgM, IgA) against glycoproteins IIb/IIIa and Ib/IX in patients with thrombocytopenia.

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[Prenatal management of fetuses with alloimmune thrombocytopenia].

Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine·1996

Area of Science:

  • Immunology
  • Transfusion Medicine
  • Hematology

Context:

  • Platelet transfusions are vital but can elicit immune responses.
  • Refractoriness to platelet transfusions presents a significant clinical challenge.
  • Understanding immune mechanisms is key to optimizing transfusion efficacy.

Purpose:

  • To review the immunological factors influencing platelet transfusion outcomes.
  • To define platelet transfusion refractoriness and its underlying causes.
  • To explore strategies for preventing and managing immunization.

Summary:

  • Discusses the definition and clinical factors of platelet transfusion refractoriness.
  • Examines antibody specificities (e.g., anti-Zwa, anti-Bra) and their role in refractory states.
  • Reviews immunological complications and the association between platelet-specific antibodies and HLA class II antigens.

Impact:

  • Provides insights into managing immune-mediated platelet transfusion refractoriness.
  • Highlights the importance of understanding antibody profiles for patient care.
  • Informs strategies to improve platelet transfusion efficacy and patient safety.

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