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[Particle formation in disposable systems for the V.50.1 (Haemonetics) cell separator]
J Misterek1, C Mueller-Eckhardt
1Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen.
Beitrage Zur Infusionstherapie = Contributions to Infusion Therapy
|January 1, 1991
Summary
Newer Haemonetics cell separator systems (V.50.1) with modified production and ceramic-polypropylene seals do not contain the previously identified small particles. This indicates a successful manufacturing update for platelet apheresis devices.
Area of Science:
- Biomedical Engineering
- Materials Science
- Hematology
Context:
- Previous studies identified small, free particles in Haemonetics V.50.1 cell separator platelet apheresis systems.
- Manufacturing processes and materials for these systems undergo continuous improvement.
- The rotating seal material was updated to ceramic-polypropylene.
Purpose:
- To investigate the presence of previously identified particles in newly developed Haemonetics V.50.1 cell separator systems.
- To assess the impact of production modifications and new seal materials on particle generation.
Summary:
- 32 newly developed Haemonetics V.50.1 cell separator systems utilizing ceramic-polypropylene rotating seals were analyzed.
- The small, free particles previously observed in earlier versions of the system were not detected in these updated systems.
- This suggests the manufacturing modifications have effectively eliminated the particles.
Impact:
- The findings indicate a resolution of particle contamination issues in platelet apheresis systems.
- This improvement may enhance the safety and efficacy of platelet collection procedures.
- The updated systems provide a potentially cleaner product for transfusion medicine.