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[Plateletpheresis with the new cell separator A 201 (Baxter)]
Beitrage Zur Infusionstherapie = Contributions to Infusion Therapy
|January 1, 1991
Summary
The new A 201 system for plateletpheresis (blood platelet collection) offers advantages like a single needle technique and reduced anticoagulation. However, it shows higher leucocyte contamination, needing improvement for routine use.
Area of Science:
- Hematology
- Medical Devices
- Blood Collection Technology
Background:
- Plateletpheresis is a critical procedure for collecting blood platelets.
- Existing apheresis systems have varying efficiencies and donor impacts.
- The Baxter Fenwal Division A 201 system represents a novel approach to platelet collection.
Purpose of the Study:
- To evaluate the initial performance and feasibility of the A 201 system for routine plateletpheresis.
- To compare the A 201 system's outcomes with established apheresis procedures.
- To identify the advantages and disadvantages of the A 201 system in clinical application.
Main Methods:
- The study involved 34 healthy donors experienced in apheresis procedures.
- The A 201 system, derived from plasmapheresis equipment, utilizes a single venipuncture and dual separation devices.
- Blood samples were collected pre-, during, and post-apheresis for analysis.
Main Results:
- Harvested platelet yields (3 +/- 0.7 x 10(11)) were comparable to other apheresis methods.
- The A 201 system demonstrated significantly higher leucocyte contamination (3.7 +/- 3.7 x 10(8)).
- Key advantages included reduced anticoagulation (6% of processed volume), single needle use, operational safety, and enhanced mobility.
Conclusions:
- The A 201 system shows promise with its user-friendly features and comparable platelet yields.
- The elevated leucocyte contamination is a notable drawback requiring further optimization.
- Despite the contamination issue, the system's benefits in anticoagulation, technique, and portability are significant.