[Neonatal alloimmune thrombocytopenia--can cryopreserved thrombocytes help? (Case report)]

We present a case report of the transfusion of cryopreserved HPA 1-negative platelets to a newborn suffering from neonatal alloimmune thrombocytopenia (NAT). A boy weighing 3450 g, born of a HPA1-negative mother with a platelet count of 9 Gpt/l after delivery, received two transfusions of cryopreserved HPA1-negative platelet concentrates. The first transfusion resulted in a platelet increment to 32 Gpt/l (CCI 11). A second transfusion was needed after a further drop of the platelet count on day 4 to 18 Gpt/l, resulting in an increment to 64 Gpt/l (CCI 36). Normal development during the first six months was obtained. In our opinion, cryopreserved HPA1-negative platelets could be helpful in the therapeutical strategy of NAT.