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Related Experiment Videos

[Tricho-epithelioma multiplex: two cases reports].

M Mseddi1, S Bouassida, S Marrekchi

  • 1Service de Dermatologie, C.H.U. H. Chker, Sfax, Tunisie.

Revue Medicale De Bruxelles
|January 30, 2007
PubMed
Summary
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Multiple trichoepitheliomas, a rare genodermatosis, typically present in younger individuals. These cases highlight unusual late-onset presentations of multiple trichoepitheliomas, emphasizing varied clinical manifestations and treatment considerations.

Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Trichoepitheliomas are benign neoplasms originating from the pilosebaceous unit.
  • Multiple trichoepithelioma (MTE) is a rare genodermatosis, typically inherited in an autosomal dominant pattern.
  • MTE commonly presents in the first or second decade of life with facial lesions.

Observation:

  • This report details two new cases of MTE in 41-year-old males.
  • Case 1: A 41-year-old male with a 2-year history of MTE, experiencing new lesion development over a 9-year follow-up, treated with local excision.
  • Case 2: A 41-year-old male presented with papulonodular facial lesions (3-30 mm) with telangiectasias, associated with milia, comedones, and alopecia areata plaques.

Findings:

  • The reported cases are atypical due to the later age of onset and significant lesion size.

Related Experiment Videos

  • Histological examination confirmed MTE in both patients.
  • MTE is often associated with other benign cutaneous tumors like cylindromas and spiradenomas.

    • Implications:

    • These cases expand the known clinical spectrum of MTE, particularly regarding age of onset and lesion characteristics.
    • While malignant transformation is rare, ongoing monitoring and appropriate treatment are essential.
    • Management is primarily driven by aesthetic concerns, with various therapeutic options available.