[Disorders of primary hemostasis caused by albumin infusion in hemodilution]

Previous studies using the In-vitro Bleeding Test have shown that albumin impairs primary hemostasis more pronouncedly than other infusion solutions. For this reason we compared ADP (4 microM)-induced platelet aggregation in samples of platelet rich plasma containing 50% albumin. We added the same amount of platelet-poor plasma to the controls. Using this method we could show the inhibitory effect of albumin once more. This means that not only changes in rheology are responsible for the impairment of hemostasis by albumin. Platelet aggregation itself is influenced.