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Chest pain and ST segment elevation attributable to cholecystitis: a case report and review of the literature
Steven J Durning1, Javed M Nasir, Jon M Sweet
1Uniformed Services University School of Medicine, Bethesda, MD 20814-4799, USA.
Insights
Gallbladder inflammation (cholecystitis) can mimic cardiac ischemia, causing chest pain and ST segment elevations. Prompt diagnosis and antibiotic treatment resolved these symptoms, highlighting the importance of considering noncardiac causes.
Area of Science:
- Cardiology
- Gastroenterology
Background:
- Chest pain with electrocardiographic changes often indicates cardiac ischemia.
- Noncardiac conditions can present with similar symptoms, leading to misdiagnosis.
Observation:
- A patient presented with chest pain and ST segment elevations mimicking acute myocardial infarction.
- Coronary angiography revealed no coronary artery disease.
- Cholecystitis was diagnosed and treated with antibiotics.
Findings:
- The patient's symptoms and electrocardiographic changes resolved with antibiotic treatment for cholecystitis.
- This case adds to the few reported instances of cholecystitis causing ST segment elevations.
Implications:
- Cholecystitis should be considered in the differential diagnosis of unexplained chest pain and ST segment elevations.
- Early recognition can prevent unnecessary cardiac interventions and ensure timely treatment for gallbladder disease.
Abstract:
Chest pain with electrocardiographic changes is usually a life-threatening presentation of cardiac ischemia. There are, however, a variety of noncardiac conditions that have been reported to mimic these clinical and electrocardiographic changes. An Asian woman presented with chest pain and ST segment elevations in the distribution of the left anterior descending artery. She had persisting chest pain and ST segment elevations that were refractory to medical therapy, leading to thrombolytic therapy and rescue angiography, which revealed no evidence of coronary artery disease by coronary catherization. Cholecystitis was subsequently diagnosed with hepatobiliary scintigraphy. The patient's fever and ST segment elevations promptly resolved with antibiotic treatment. Four previous cases of ST segment elevation attributed to cholecystitis have been reported. Although the electrocardiographic changes attributed to cholecystitis have been shown to be correctable, the pathophysiological mechanism underlying these changes remains unclear. Prompt recognition of cholecystitis can ensure appropriate treatment and may prevent the performance of unnecessary diagnostic and therapeutic interventions.
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