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Guaiane sesquiterpene lactones from Salvia nubicola (Lamiaceae)
Muhammad S Ali1, Syed A Ibrahim, Shakeel Ahmed
1H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. shaiq303@hotmail.com
Abstract:
A new sesquiterpene lactone, nubiol (1), belonging to the guaiane class, along with a dimer, bisnubidiol (2), has been isolated from Salvia nubicola collected from Quetta, Pakistan. The structures of both metabolites were elucidated with the aid of spectroscopic techniques including 2D-NMR. Additionally, the structure of nubiol (1) was finally confirmed via the single crystal X-ray diffraction. Nubiol (1) was found moderately active against Pseudomonas aeruginosa.