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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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Biomarkers for phenol carcinogen exposure act as pH-sensing fluorescent probes

Kewen M Sun1, Christopher K McLaughlin, Dean R Lantero

  • 1Department of Chemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1.

Journal of the American Chemical Society
|January 30, 2007
PubMed
Abstract

No abstract available in PubMed .

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Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...