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Articles linked to this work by shared authors, journal, and citation graph.

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Novel application of acetazolamide to reduce cerebrospinal fluid production in patients undergoing thoracoabdominal aortic surgery.

Interactive cardiovascular and thoracic surgery·2013
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The frozen elephant trunk for the treatment of chronic dissection of the thoracic aorta: a multicenter experience.

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Recommendations for haemodynamic and neurological monitoring in repair of acute type a aortic dissection.

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Editorial comment Redo proximal aortic surgery--lessons from Bologna.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2011
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A paradigm shift in aortic arch surgery, certainly--but corroboration required.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2011
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The brain, the spinal cord, selective antegrade cerebral perfusion and corporeal arrest temperature - are we reducing the margin of patient safety in aortic arch surgery?

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2009

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Cerebral perfusion.

Deborah K Harrington1, Fernanda Fragomeni, Robert Stuart Bonser

  • 1Department of Cardiac Surgery, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, United Kingdom.

The Annals of Thoracic Surgery
|January 30, 2007
PubMed
Summary
This summary is machine-generated.

Aortic arch surgery poses brain injury risks. Selective antegrade cerebral perfusion is preferred, but optimal delivery and perfusate conditions need more research for better brain protection.

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Area of Science:

  • Cardiovascular Surgery
  • Neurology
  • Perfusion Technology

Background:

  • Aortic arch surgery requires temporary cessation of brain blood flow, increasing the risk of neurological damage.
  • Established brain protection strategies include hypothermic circulatory arrest, retrograde cerebral perfusion, and selective antegrade cerebral perfusion.
  • Understanding the physiological effects of deep hypothermia is crucial for managing circulatory arrest duration.

Purpose of the Study:

  • To review current brain protection techniques during aortic arch surgery.
  • To evaluate the efficacy and limitations of different perfusion strategies.
  • To identify areas for future research in optimizing cerebral protection.

Main Methods:

  • Review of existing literature on brain protection during aortic arch surgery.
  • Analysis of pathophysiological consequences of hypothermia and perfusion techniques.
  • Comparison of outcomes associated with hypothermic arrest, retrograde, and antegrade cerebral perfusion.

Main Results:

  • Retrograde cerebral perfusion, while intended to extend safe arrest times, has not conclusively improved patient outcomes.
  • Selective antegrade cerebral perfusion is emerging as the favored method for protecting the brain during these procedures.
  • Current evidence suggests that the specific conditions for delivering antegrade perfusion and the composition of the perfusate require further investigation.

Conclusions:

  • Selective antegrade cerebral perfusion is currently the preferred brain protection strategy in aortic arch surgery.
  • Further research is essential to define optimal delivery parameters and perfusate characteristics for antegrade cerebral perfusion.
  • Refining these techniques may further mitigate the risk of brain injury in complex aortic arch reconstructions.