Related Experiment Video

Updated: Jul 17, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
08:49

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Severe left ventricular hypertrophy 1 year after transplant predicts mortality in cardiac transplant recipients

Randy Goodroe1, D Dirk Bonnema, Shayna Lunsford

  • 1Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina 29425, USA.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|January 30, 2007
PubMed

Insights

Left ventricular hypertrophy (LVH) is prevalent in heart transplant recipients and predicts mortality. Pre-transplant hypertension is a key risk factor for developing severe LVH post-transplant.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Cardiac Imaging

Background:

  • Left ventricular hypertrophy (LVH) is a known predictor of adverse outcomes in essential hypertension.
  • The prevalence and clinical significance of LVH in heart transplant recipients remain largely unknown.

Purpose of the Study:

  • To determine the prevalence of LVH one year after heart transplantation.
  • To identify predictors of LVH in this patient population.
  • To assess the impact of LVH on survival post-transplant.

Main Methods:

  • 141 heart transplant recipients underwent transthoracic echocardiograms one year post-transplant.
  • Data on demographics and left ventricular mass (LVM) were collected and analyzed.
  • Patients were categorized into normal, mild-moderate, and severe LVH groups based on LVM.

Main Results:

  • LVH was present in 83% of heart transplant recipients at one year.
  • Pre-transplant hypertension was an independent predictor of severe LVH (HR 2.3).
  • Severe LVH independently predicted increased mortality (HR 3.6) after adjusting for covariates.

Conclusions:

  • LVH is common one year after heart transplantation and is a significant predictor of mortality.
  • Pre-transplant hypertension independently predicts the development of severe LVH post-transplant.
Abstract

More Related Videos

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation09:12

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

Published on: April 27, 2019

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...