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Updated: Jul 17, 2026

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Published on: June 2, 2014
Possible joint origin of restless leg syndrome (RLS) and migraine
Behnam Sabayan1, Mansooreh Bagheri, Afshin Borhani Haghighi
1Student Research Committee, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:
Sleep disorders have been described in migraine patients. Among sleep disorders RLS has been reported in up to one-third of migraineurs. Adverse effects of anti migraine therapy by dopamine antagonists can not fully explain this association. Therefore we present the hypothesis that RLS and migraine may have a joint origin. The hypothesis is supported by: (1) the same genetic origin for migraine without aura and RLS in single Italian family on chromosome 14q21; this gene codes survival motor neuron-interacting protein 1 (SIP1) which can play role in both diseases. (2) Correlation of both RLS and migraine with fibromyalgia. (3) Alteration of cortical excitability in both migraine and RLS.
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