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Characterization of the gene-product of the Steel locus
1Department of Experimental Hematology (DEW), Immunex Research and Development Corporation, Seattle, WA 98101.
Progress in Growth Factor Research
|January 1, 1991
Abstract:
Steel factor (SLF) (aka: mast cell growth factor, stem cell factor, kit ligand) is the product of the murine Steel locus on chromosome 10 and is a ligand for the c-kit protooncogene. Isolation of cDNAs for SLF revealed that it was a membrane bound growth factor. Proteolytic processing releases a soluble version of the growth factor which has been shown to promote a wide variety of biological functions. In this review we focus on the cellular and molecular biology of SLF.