Related Experiment Video
Updated: Jul 17, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Familial dysphagia and eosinophilia
David A Zink1, Mitual Amin, Souheil Gebara
1Division of Gastroenterology and Hepatology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.
Background:
Recent reports suggest a familial predisposition to eosinophilic esophagitis (EE) and a link between Schatzki's rings and EE.
Objective:
Our objective is to present our experience with 7 families with dysphagia and eosinophilia.
Design:
Case series.
Setting:
One-thousand-bed community-based teaching hospital.
Patients:
Seventeen patients from 7 families with dysphagia and eosinophilia.
Methods:
Direct clinical and endoscopic examination with review of radiologic and pathologic data.
Results:
Twelve patients had EE alone, one had eosinophilic gastroenteritis (EG) alone, one had EE and EG, and 3 geriatric patients had Schatzki's rings (one with EG and peripheral eosinophilia [PE] and one with PE). EE spanned 2 generations in 4 families and involved 2 brothers in one family.
Limitations:
This was a case series.
Conclusion:
We propose a familial dysphagia syndrome characterized by eosinophilia in the form of EE, EG, or PE and Schatzki's rings in older generations.
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