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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link?

Susan E Quaggin, Thomas M Coffman

    Journal of the American Society of Nephrology : JASN
    |January 30, 2007
    PubMed
    Abstract

    No abstract available in PubMed .

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    Diabetic Nephropathy01:28

    Diabetic Nephropathy

    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...