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Related Experiment Video

Updated: Jul 17, 2026

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Optimizing intracranial metastasis detection for stereotactic radiosurgery.

Johnathan A Engh¹, John C Flickinger, Ajay Niranjan

¹Department of Neurological Surgery, University of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Stereotactic and Functional Neurosurgery

|January 30, 2007

Summary

A specialized high-resolution MRI protocol accurately detects additional brain metastases in cancer patients before stereotactic radiosurgery (SRS). This improved detection impacts treatment planning for various therapies.

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Area of Science:

Neuro-oncology
Radiology
Medical Imaging

Background:

Intracranial metastases significantly impact cancer patient prognosis.
Accurate staging of brain metastases is crucial for effective treatment planning.

Purpose of the Study:

To evaluate a specialized high-resolution magnetic resonance imaging (MRI) protocol for detecting additional intracranial metastases.
To assess the impact of this protocol on treatment planning for stereotactic radiosurgery (SRS).

Main Methods:

Retrospective review of 150 cancer patients undergoing SRS.
Utilized a specialized 1.5-tesla MRI with double-dose gadolinium and 2-mm axial cuts.
Rigid head fixation in a stereotactic frame was employed.

Main Results:

Additional metastases were detected in 29.3% of patients.
Predictive factors for additional metastases included 3-5 known tumors, non-small cell lung cancer, and longer intervals between MRIs.
Number of known tumors before SRS predicted additional metastases (p=0.014).

Conclusions:

The specialized high-resolution MRI protocol reliably assesses intracranial disease extent in patients with brain metastases.
Improved metastasis detection influences planning for SRS, radiation therapy, and surgery.