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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Osteosarcoma and acromegaly: a case report and review of the literature

G A B Lima1, E M S Gomes, R C Nunes

  • 1Division of Endocrinology, Department of Internal Medicine, Clementino Fraga Filho University Hospital/Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Journal of Endocrinological Investigation
|January 30, 2007
PubMed

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Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...