Growth-associated protein-43 expression in the lens of rats and primates

Growth-associated protein-43 is a specific neuronal protein that regulates differentiation, growth and plasticity. In the present study, growth-associated protein-43 expression was studied in the lens of rats and primates (including man) at different postnatal ages by immunoblotting, immunohistochemistry and quantitative real-time polymerase chain reaction. Growth-associated protein-43 was expressed at all ages in primates and in developing, but not in adult rats. We demonstrate that the lens - a tissue that is devoid of nerves - expresses growth-associated protein-43 throughout life in primates, and in rats during development but not in adulthood. These results suggest that growth-associated protein-43 is involved in differentiation processes also outside the nervous system.