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Updated: Jul 17, 2026

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
Humanized mice in translational biomedical research
Leonard D Shultz1, Fumihiko Ishikawa, Dale L Greiner
1The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. lds@jax.org
Abstract:
The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.
