Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pyruvate kinase muscle 2 (PKM2) promotes CD4 T cell survival by regulating pyruvate oxidation during homeostasis and expansion.

Science advances·2026
Same author

IL-7 promotes the formation of DNA double strand breaks and DNA repair in murine pro-B cells.

Frontiers in immunology·2025
Same author

<i>Staphylococcus aureus</i> proteases trigger eosinophil-mediated skin inflammation.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Correction: The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells.

Gut pathogens·2023
Same author

Mechanism of co-operation of mutant <i>IL-7R</i>α and mutant <i>NRAS</i> in acute lymphoblastic leukemia: role of MYC.

Haematologica·2023
Same author

Methotrexate-based PROTACs as DHFR-specific chemical probes.

Cell chemical biology·2023

Related Experiment Video

Updated: Jul 17, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Interleukin-7 receptor expression: intelligent design.

Renata Mazzucchelli1, Scott K Durum

  • 1Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 560, Room 31-71, Frederick, Maryland 21702-1201, USA.

Nature Reviews. Immunology
|January 30, 2007
PubMed
Summary

Interleukin-7 (IL-7) is crucial for T cell development and survival. The amount of IL-7 receptor on T cells influences IL-7 consumption, thereby regulating its availability in lymphoid tissues.

More Related Videos

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
08:38

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Jul 17, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
08:38

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • Interleukin-7 (IL-7) is essential for T cell development and peripheral maintenance.
  • Stromal cells in lymphoid tissues are the primary source of IL-7.
  • Unlike other cytokines, IL-7 production is largely independent of external stimuli.

Purpose of the Study:

  • To review the regulatory mechanisms of Interleukin-7 (IL-7) availability in lymphoid niches.
  • To explore the role of IL-7 receptor expression in T cell-mediated IL-7 consumption.
  • To understand how T cell-intrinsic factors affect the IL-7 supply.

Main Methods:

  • Literature review of existing studies on IL-7 biology and T cell-cytokine interactions.
  • Analysis of data on IL-7 receptor expression levels and their correlation with T cell function.
  • Examination of models describing cytokine scavenging by immune cells.

Main Results:

  • IL-7 production by stromal cells is relatively constant and not easily modulated by external factors.
  • The amount of IL-7 receptor expressed on T cells directly impacts their efficiency in scavenging IL-7.
  • T cell IL-7 receptor density is a key determinant of IL-7 availability within the microenvironment.

Conclusions:

  • T cell IL-7 receptor expression is a critical regulator of the IL-7 supply-demand balance.
  • Modulation of IL-7 receptor levels on T cells can significantly influence T cell persistence and function.
  • Understanding this regulatory axis is vital for comprehending immune homeostasis and developing targeted therapies.