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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: Jul 17, 2026

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
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Published on: June 14, 2018

Imaging inflammation in acute brain ischemia.

Sebastian Jander1, Michael Schroeter, Andreas Saleh

  • 1Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany. jander@uni-duesseldorf.de

Stroke
|January 31, 2007
PubMed
Summary

Brain inflammation is a key target for treating ischemic stroke. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles aid in visualizing macrophage activity via MRI, offering insights into stroke lesion development.

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Published on: December 28, 2014

Area of Science:

  • Neuroscience
  • Immunology
  • Radiology

Background:

  • Brain inflammation plays a crucial role in the subacute stages of ischemic stroke.
  • The innate immune system, particularly microglia/brain macrophages and monocytes/macrophages, dominates post-stroke inflammation.
  • Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are emerging as cell-specific MRI contrast agents.

Purpose of the Study:

  • To investigate the utility of USPIO-enhanced MRI in visualizing macrophage activity in ischemic stroke.
  • To explore the role of macrophages in the development of ischemic brain lesions.
  • To assess USPIO-enhanced MRI as a tool for both basic science and clinical stroke research.

Main Methods:

  • Intravenous injection of USPIO nanoparticles into subjects with ischemic stroke.
  • Utilizing MRI to detect signal changes caused by USPIO uptake in phagocytic cells.
  • Analyzing the distribution and impact of USPIO-laden macrophages within the infarcted brain parenchyma.

Main Results:

  • USPIO nanoparticles are effectively taken up by circulating phagocytic cells, including macrophages.
  • USPIO-laden macrophages induce characteristic signal alterations in MRI scans of infarcted brain tissue.
  • These findings were observed in both experimental models of ischemia and human stroke cases.

Conclusions:

  • USPIO-enhanced MRI can visualize macrophage infiltration and activity in ischemic stroke.
  • This technique provides valuable insights into the cellular mechanisms of ischemic lesion development.
  • USPIO-enhanced MRI represents a promising tool for advancing stroke research and clinical diagnostics.