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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: Jul 17, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Postinfarct cortical plasticity and behavioral recovery.

Randolph J Nudo1

  • 1KU Medical Center, Landon Center on Aging, Kansas City, KS 66160, USA.

Stroke
|January 31, 2007
PubMed
Summary

Brain plasticity after stroke involves functional changes in spared areas and rerouted neural pathways. Behavioral experience significantly modifies these recovery mechanisms, offering insights into the brain

Area of Science:

  • Neuroscience
  • Cerebral Cortex Research
  • Stroke Recovery Studies

Background:

  • Plasticity in the cerebral cortex post-ischemic injury is well-documented in animal models and human stroke survivors.
  • Understanding the neuroanatomic and neurophysiological changes is crucial for stroke recovery research.

Purpose of the Study:

  • To review major neuroanatomic and neurophysiological changes characterizing post-stroke plasticity in experimental animals.
  • To discuss recent findings on the rerouting of long-range intracortical pathways.
  • To explore the implications for understanding the brain's recovery capacity.

Main Methods:

  • Review of existing literature on experimental animal models of ischemic injury.
  • Analysis of neuroanatomic and neurophysiological data.

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Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique
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Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique

Published on: June 2, 2016

Related Experiment Videos

Last Updated: Jul 17, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique
08:25

Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique

Published on: June 2, 2016

  • Synthesis of recent evidence on intracortical pathway modifications.

    • Main Results:

    • Spared cortical regions adjacent and distant to the infarct exhibit functional alterations.
    • These alterations are modulated by behavioral experiences.
    • Long-range intracortical pathways demonstrate the capacity to reroute to novel territories.

    Conclusions:

    • Post-stroke plasticity involves significant functional reorganization in the cerebral cortex.
    • Behavioral experience plays a key role in shaping recovery.
    • The brain's ability to reroute neural pathways offers new perspectives on stroke recovery potential.