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The evolution of epidemic influenza
Martha I Nelson1, Edward C Holmes
1Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Nature Reviews. Genetics
|January 31, 2007
Summary
Human influenza virus evolution is better understood through genomic sequencing and modeling. Further research into genetic diversity, especially in tropical regions, is needed to explain the virus's seasonality.
Area of Science:
- Virology
- Epidemiology
- Genomics
Background:
- Advances in complete-genome sequencing, antigenic mapping, and epidemiological modeling enhance understanding of human influenza virus evolution.
- Recent studies reveal a complex interplay between antigenic evolution, natural selection, and reassortment in influenza viruses.
Observation:
- Despite progress, key aspects of influenza virus epidemiology remain unclear, particularly the drivers of its pronounced seasonality.
- Current knowledge gaps exist regarding the virus's evolutionary biology at a granular level.
Findings:
- A comprehensive genomic perspective is crucial for fully understanding influenza virus evolution.
- Acquiring polymorphism data from within hosts and under-surveyed regions like the tropics is essential.
Implications:
- This genomic approach will improve our understanding of influenza virus seasonality.
- Further research can inform public health strategies for managing influenza.
- Targeted data collection in the tropics may reveal novel evolutionary insights.
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